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KMID : 0857020100250010059
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Kosin Medical Journal
2010 Volume.25 No. 1 p.59 ~ p.65
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Ki-67 index, Luminal B Type, and Prognosis of Patients with Breast Cancer
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Ryu Dong-Won
Choi Woo-Sik
Lee Chung-Han
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Abstract
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Background: Ki-67 expression has been considered to be a reliable marker for assessing tumor cell proliferation. The aims of the ourstudy were to assess the correlationbetween Ki-67 expression and clinocopathologic factors and to analyze the effect of Ki-67 expression on survival rate.
Methods:The study subjects, 679 women with breast cancer, were a subset of patients operated at OOO hospital from Jun 2001 to Dec 2005.Patients are grouped into 3 categories according to Ki-67 determined in surgical specimens. Clincopathologic factors were compared with 3 categories of Ki-67. Chi-squared tests were used for statistical analysis. Kaplan?Meier estimates are presented for thesurvival function, and differences in survival were analyzed usingthe log rank test.
Results: The median age was 46yrs, and median tumor size was 3.2cm. The strong correlation was observed between tumor staging and Ki-67 staining(p=0.007) and Group III(more than 20% staing) showed more advanced N-staging(p=0.003). The number of patients with estrogen receptor negative was higher in Group III(p=0.001) and that with HER-2 receptor positive was also higher in Group III(p =0.001) comparing with other groups. The univariate analysis for prognostic factors associated with DFS revealed that both the tumor groupas T1, T2, T3 or T4 and lymph node as N0, N1, N2 or N3 were statistically significant(p=0.0003 and p=0.0015 respectively) but the Ki-67 staining as <10%, 10~20%, >20% was statistically not significant(p=0.6112). The univariate analysis for prognostic factors associated with OS revealed that Tumor staging
and N-staging was statically significant(p=0.003 and p=0.0015 respectively).
Conclusions: According to our study, Ki-67 positive groups was associated with more advanced staging, ER-negative, PR-negative and HER-positive respectively. But there is no significant association between Ki-67 staining and 5-year disease free survival rate including overall survival rate.
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KEYWORD
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Ki67, breast cancer, survival rate, T-stage, N-stage, Luminal B
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